Coprecipitation of calcium hydroxyapatite, graphene oxide, and chitosan from aqueous solutions

We determined the character of interactions between calcium hydroxyapatite Са10(РO4)6(ОН)2 (HA), graphene oxide (GO), and chitosan (С6Н11NO4)n (CHT) to yield HA/CHT/GO nanocomposites (NCs) in the СаС12–(NH4)2НРО4–NH3–Н2О–(С6Н11NO4)n–GO system (25°С). A set of physicochemical methods helped us to elucidate composition–synthesis parameters–structure–particle size–properties correlations for the prepared NCs and to prove the feasibility to manufacture NCs with tailored HA, CHT, and GO contents, described by the bulk formula Са10(РО4)6(ОН)2 · х(С6Н11NO4)n · yGO · zН2О, where х = 0.1, 0.2, 0.3; y = 0.6, 1.2, 2.4; and z = 6.0–7.4.