MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

被引：0
|
作者：
Huadong Pei
Lindsey Zhang
Kuntian Luo
Yuxin Qin
Marta Chesi
Frances Fei
P. Leif Bergsagel
Liewei Wang
Zhongsheng You
Zhenkun Lou
机构：
[1] Mayo Clinic,Division of Oncology Research
[2] Washington University,Department of Cell Biology and Physiology
[3] Mayo Clinic,Department of Molecular Pharmacology and Experimental Therapeutics
[4] Comprehensive Cancer Center,undefined
[5] Mayo Clinic Arizona,undefined
来源：
Nature | 2011年 / 470卷
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摘要：
Recruitment of p53 binding protein 1 (53BP1) to double-strand DNA breaks is an important step in the cellular response to DNA damage. Here, the histone methyltransferase MMSET is shown to be responsible for localized increases in a histone modification that is involved in recruiting 53BP1. The mechanism of MMSET recruitment to DNA damage sites is also investigated.
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页码：124 / 128
页数：4
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