Allelic variants of PRNP in 16 Chinese local sheep breeds

被引：0

作者：

Zouran Lan

Jinming Li

Chengyou Sun

Yutian Liu

Yonggang Zhao

Tianying Chi

Xiaojing Yu

Fangfang Song

Zhiliang Wang

机构：

[1] China Animal Health and Epidemiology Center,

[2] Shandong Center for Animal Disease Control and Prevention,undefined

来源：

Archives of Virology | 2014年 / 159卷

关键词：

Bovine Spongiform Encephalopathy; Scrapie; Sheep Breed; Chronic Wasting Disease; PRNP Gene;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Here, polymorphisms of the ovine prion protein gene were analyzed in 486 Chinese sheep from 16 main local breeds. Polymorphisms R or H at codons 154 and four polymorphisms at codon 171 encoding Q, R, H, or K were identified. The A/V polymorphism at codon 136 was not observed, and all sheep were homozygous for A at this position. In addition, ten polymorphisms at codons 21, 101, 112, 127, 138, 141, 143, 146, 153 and 189 were detected. The predominant Q allele occurred at codon 171, with a high frequency of 88.68 %, implying a risk of scrapie in China.

引用

页码：2141 / 2144

页数：3

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