Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

被引：0
|
作者：
Tomasz Cierpicki
Laurie E Risner
Jolanta Grembecka
Stephen M Lukasik
Relja Popovic
Monika Omonkowska
David D Shultis
Nancy J Zeleznik-Le
John H Bushweller
机构：
[1] University of Virginia,Department of Molecular Physiology and Biological Physics
[2] Molecular Biology Program,Department of Medicine
[3] Oncology Institute,Department of Chemistry
[4] Loyola University,undefined
[5] University of Virginia,undefined
[6] These authors contributed equally to this work. Present address: Department of Pathology,undefined
[7] University of Michigan,undefined
[8] Ann Arbor,undefined
[9] Michigan,undefined
[10] USA (T.C. and J.G.).,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MLL fusions are linked to leukemias and retain the CXXC domain, which binds unmethylated DNA. The NMR structure of CXXC–DNA now indicates the interactions underlying binding. Mutation of a key residue to a nonbinding form decreases proliferation caused by an MLL-AF9 fusion and leukemias induced by MLL-AF9 expression in mice.
引用
收藏
页码：62 / 68
页数：6
相关论文
共 50 条
  • [1] Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia
    Cierpicki, Tomasz
    Risner, Laurie E.
    Grembecka, Jolanta
    Lukasik, Stephen M.
    Popovic, Relja
    Omonkowska, Monika
    Shultis, David D.
    Zeleznik-Le, Nancy J.
    Bushweller, John H.
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (01) : 62 - U82
  • [2] Structural Basis for MLL Cxxc Domain Protection against CpG DNA Methylation and the Essential Role of This Function in MLL-AF9 Leukemia
    Risner, Laurie
    Cierpicki, Tomasz
    Grembecka, Jolanta
    Lukasik, Stephen M.
    Popovic, Relja
    Shultis, David S.
    Zeleznik-Le, Nancy J.
    Bushweller, John H.
    BLOOD, 2009, 114 (22) : 317 - 317
  • [3] Aggressive leukemia driven by MLL-AF9
    Stavropoulou, Vaia
    Peters, Antoine H. F. M.
    Schwaller, Juerg
    MOLECULAR & CELLULAR ONCOLOGY, 2018, 5 (03):
  • [4] Integrin β3 in MLL-AF9 leukemia
    Feliciano P.
    Nature Genetics, 2013, 45 (8) : 851 - 851
  • [5] Polycomb repressive complex 2 is required for MLL-AF9 leukemia
    Neff, Tobias
    Sinha, Amit U.
    Kluk, Michael J.
    Zhu, Nan
    Khattab, Mohamed H.
    Stein, Lauren
    Xie, Huafeng
    Orkin, Stuart H.
    Armstrong, Scott A.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (13) : 5028 - 5033
  • [6] The Role of the Intrinsically Disordered and Multifunctional AF9 C-Terminal Domain in MLL-AF9 Leukemia
    Bushweller, John H.
    Leach, Benjamin
    Chang, Ming-jin
    Lumba, Bhavna
    Cierpicki, Tomasz
    Zeleznik-Le, Nancy J.
    Hemenway, Charles S.
    BLOOD, 2011, 118 (21) : 1480 - 1480
  • [7] Neonatal acute lymphoblastic leukemia (MLL-AF9) with leukemia cutis
    Yin, Yu-Tsung
    Tseng, Ju-Huei
    Liu, Yen-Lin
    Miser, James S.
    Chen, Shu-Huey
    PEDIATRICS AND NEONATOLOGY, 2021, 62 (06): : 676 - 678
  • [8] Intrinsic Disorder, Epigenetics, and Leukemia - the MLL-AF9 SAGA
    Bushweller, John
    Kuntimaddi, Aravinda
    Thorpe, Jeremy
    Achille, Nicholas
    Lokken, Alyson
    Singh, Ritambhara
    Adli, Mazhar
    Zeleznik-Le, Nancy
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 5A - 5A
  • [9] Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
    Liu, Y.
    Cheng, H.
    Gao, S.
    Lu, X.
    He, F.
    Hu, L.
    Hou, D.
    Zou, Z.
    Li, Y.
    Zhang, H.
    Xu, J.
    Kang, L.
    Wang, Q.
    Yuan, W.
    Gao, S.
    Cheng, T.
    LEUKEMIA, 2014, 28 (05) : 1071 - 1080
  • [10] Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
    Y Liu
    H Cheng
    S Gao
    X Lu
    F He
    L Hu
    D Hou
    Z Zou
    Y Li
    H Zhang
    J Xu
    L Kang
    Q Wang
    W Yuan
    S Gao
    T Cheng
    Leukemia, 2014, 28 : 1071 - 1080
12345