Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

被引：0

作者：

Joshua Munger

Bryson D Bennett

Anuraag Parikh

Xiao-Jiang Feng

Jessica McArdle

Herschel A Rabitz

Thomas Shenk

Joshua D Rabinowitz

机构：

[1] Lewis Thomas Laboratory,Department of Molecular Biology

[2] Princeton University,Department of Biochemistry and Biophysics

[3] University of Rochester School of Medicine and Dentistry,Department of Chemistry and Lewis

[4] 601 Elmwood Ave,Sigler Institute for Integrative Genomics

[5] Box 712,Department of Chemistry

[6] Rochester,undefined

[7] New York 14642,undefined

[8] USA,undefined

[9] Carl Icahn Laboratory,undefined

[10] Princeton University,undefined

[11] Frick Laboratory,undefined

[12] Princeton University,undefined

来源：

Nature Biotechnology | 2008年 / 26卷

关键词：

D O I：

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学科分类号：

摘要：

Munger et al. show that infection with human cytomegalovirus upregulates fatty acid biosynthesis and that pharmacological inhibition of this pathway inhibits replication of both this virus and influenza A. This approach, the first to reliably map major carbon fluxes in mammalian cells, extends the promise of metabolomics from diagnostic applications to identification of new therapeutic concepts.

引用

页码：1179 / 1186

页数：7

共 22 条

[1] Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
Munger, Joshua
Bennett, Bryson D.
Parikh, Anuraag
Feng, Xiao-Jiang
McArdle, Jessica
Rabitz, Herschel A.
Shenk, Thomas
Rabinowitz, Joshua D.
NATURE BIOTECHNOLOGY, 2008, 26 (10) : 1179 - 1186
[2] Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum
Amador-Noguez, Daniel
Feng, Xiao-Jiang
Fan, Jing
Roquet, Nathaniel
Rabitz, Herschel
Rabinowitz, Joshua D.
JOURNAL OF BACTERIOLOGY, 2010, 192 (17) : 4452 - 4461
[3] Systems-level analysis of mechanisms regulating yeast metabolic flux
Hackett, Sean R.
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Xu, Wenxin
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Park, Junyoung O.
Perlman, David H.
Gibney, Patrick A.
Botstein, David
Storey, John D.
Rabinowitz, Joshua D.
SCIENCE, 2016, 354 (6311)
[4] Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum (vol 192, pg 4452, 2010)
Amador-Noguez, Daniel
Feng, Xiao-Jiang
Fan, Jing
Roquet, Nathaniel
Rabitz, Herschel
Rabinowitz, Joshua D.
JOURNAL OF BACTERIOLOGY, 2011, 193 (23) : 6805 - 6805
[5] A systems-level, semi-quantitative landscape of metabolic flux in C. elegans
Zhang, Hefei
Li, Xuhang
Tseyang, L. Tenzin
Giese, Gabrielle E.
Wang, Hui
Yao, Bo
Zhang, Jingyan
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Spinelli, Jessica B.
Yilmaz, L. Safak
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NATURE, 2025, 640 (8057) : 194 - 202
[6] A systems-level approach identifies novel links between iron and fatty acid metabolism in high-grade serous ovarian cancer
Konstorum, Anna
Lynch, Miranda L.
Torti, Suzy V.
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[7] The fatty acid synthesis pathway as a target for obesity therapy
Ronnett, GV
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FASEB JOURNAL, 2005, 19 (05): : A1691 - A1691
[8] An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling
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Zain Zuberi
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Scientific Reports, 12
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SCIENTIFIC REPORTS, 2022, 12 (01)
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Manuela Mazzuferi
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Benedicte Danis
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