Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

被引：0

作者：

Kazuaki Yoshioka

Kotaro Yoshida

Hong Cui

Tomohiko Wakayama

Noriko Takuwa

Yasuo Okamoto

Wa Du

Xun Qi

Ken Asanuma

Kazushi Sugihara

Sho Aki

Hidekazu Miyazawa

Kuntal Biswas

Chisa Nagakura

Masaya Ueno

Shoichi Iseki

Robert J Schwartz

Hiroshi Okamoto

Takehiko Sasaki

Osamu Matsui

Masahide Asano

Ralf H Adams

Nobuyuki Takakura

Yoh Takuwa

机构：

[1] Kanazawa University School of Medicine,Department of Physiology

[2] Kanazawa University School of Medicine,Department of Radiology

[3] Kanazawa University School of Medicine,Department of Histology and Embryology

[4] Ishikawa Prefectural Nursing University,Department of Health and Medical Sciences

[5] Akita University Graduate School of Medicine,Department of Medical Biology

[6] Advanced Science Research Center,Division of Transgenic Animal Science

[7] Kanazawa University,Department of Signal Transduction

[8] Research Institute for Microbial Diseases,Department of Biology and Biochemistry

[9] Osaka University,Department of Medical Biochemistry

[10] University of Houston,Department of Tissue Morphogenesis

[11] Tohoku University School of Medicine,undefined

[12] Research Center for Biosignal,undefined

[13] Akita University,undefined

[14] Max Planck Institute for Molecular Biomedicine,undefined

[15] University of Muenster,undefined

[16] Faculty of Medicine,undefined

来源：

Nature Medicine | 2012年 / 18卷

关键词：

D O I：

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学科分类号：

摘要：

Although type I phosphatidylinositol 3-kinases (PI3Ks) are well studied signaling proteins, the functions of other PI3Ks are more enigmatic. Kazuaki Yoshioka et al. find that the type II PI3K-2α isoform regulates endosomal trafficking and cell signaling in endothelial cells. Angiogenic and vascular permeability responses are attenuated in mice lacking PI3K-2α, pointing to this enzyme as a potential target for treating vascular disease.

引用

页码：1560 / 1569

页数：9

共 50 条

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