The State of Cholinergic Structures in Forebrain of Bulbectomized Mice

被引：0
|
作者：
N. V. Bobkova
I. V. Nesterova
V. V. Nesterov
机构：
[1] Institute of Cell Biophysics,
来源：
Bulletin of Experimental Biology and Medicine | 2001年 / 131卷
关键词：
acetylcholinergic system of basal forebrain structures; choline acetyltransferase; bulbectomy; spatial memory;
D O I：
暂无
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学科分类号：
摘要：
The effects of bulbectomy on the state of basal forebrain cholinergic structures and spatial memory in Morris water maze were studied. Immunostaining with polyclonal antibodies to choline acetyltransferase AB144P revealed decreased density of immunoreactive cells in the horizontal limb of the diagonal band of Broca (55% of control), basal magnocellular preoptic nucleus (58.9%), and the caudate nucleus-putamen complex (68.2%). No significant changes in the vertical limb of the diagonal band of Broca and globus pallidus were observed. These findings and published data allow us to assume that pathology of the olfactory bulb can underlie memory impairment during Alzheimer's disease associated with dysfunction of acetylcholine-synthesizing structures in the forebrain.
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页码：427 / 431
页数：4
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