Advancing genomics to improve health equity

被引：2

作者：

Madden, Ebony B. ^{[1
]}

Hindorff, Lucia A. ^{[1
]}

Bonham, Vence L. ^{[1
]}

Akintobi, Tabia Henry ^{[2
]}

Burchard, Esteban G. ^{[3
]}

Baker, Kellan E. ^{[4
]}

Begay, Rene L. ^{[5
]}

Carpten, John D. ^{[6
]}

Cox, Nancy J. ^{[7
]}

Di Francesco, Valentina ^{[1
]}

Dillard, Denise A. ^{[8
]}

Fletcher, Faith E. ^{[9
]}

Fullerton, Stephanie M. ^{[10
]}

Garrison, Nanibaa' A. ^{[11
,12
,13
]}

Hammack-Aviran, Catherine M. ^{[14
]}

Hiratsuka, Vanessa Y. ^{[15
]}

Hildreth, James E. K. ^{[16
]}

Horowitz, Carol R. ^{[17
]}

Halbert, Chanita A. Hughes ^{[18
]}

Inouye, Michael ^{[19
]}

Jackson, Amber ^{[1
]}

Landry, Latrice G. ^{[20
]}

Kittles, Rick A. ^{[21
]}

Leek, Jeff T. ^{[22
]}

Limdi, Nita A. ^{[23
]}

Lockhart, Nicole C. ^{[1
]}

Ofili, Elizabeth O. ^{[24
]}

Perez-Stable, Eliseo J. ^{[25
]}

Sabatello, Maya ^{[26
,27
]}

Saulsberry, Loren ^{[28
]}

Schools, Lorjetta E. ^{[29
]}

Troyer, Jennifer L. ^{[1
]}

Wilfond, Benjamin S. ^{[30
]}

Wojcik, Genevieve L. ^{[31
]}

Cho, Judy H. ^{[17
]}

Lee, Sandra S. -J. ^{[27
]}

Green, Eric D. ^{[1
]}

机构：

[1] NHGRI, Off Director, Bethesda, MD 20892 USA

[2] Morehouse Sch Med, Dept Community Hlth & Preventat Med, Atlanta, GA USA

[3] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

[4] Whitman Walker Inst, Whitman, WA USA

[5] Univ Colorado, Ctr Amer Indian & Alaska Native Hlth, Anschutz Med Campus, Aurora, CO USA

[6] Comprehens Canc Ctr, City Hope, Duarte, CA USA

[7] Vanderbilt Univ, Vanderbilt Genet Inst, Nashville, TN USA

[8] Washington State Univ, Dept Med Educ & Clin Sci, Coll Med, Seattle, WA USA

[9] Baylor Coll Med, Ctr Med Eth & Hlth Policy, Houston, TX USA

[10] Univ Washington, Dept Bioeth & Humanities, Seattle, WA USA

[11] Univ Calif Los Angeles, Inst Soc & Genet, Los Angeles, CA USA

[12] UCLA, David Geffen Sch Med, Inst Precis Hlth, Los Angeles, CA USA

[13] UCLA, Div Gen Internal Med & Hlth Serv Res, David Geffen Sch Med, Los Angeles, CA USA

[14] Vanderbilt Univ, Dept Hlth Policy, Nashville, TN USA

[15] Univ Alaska Anchorage, Ctr Human Dev, Anchorage, AK USA

[16] Meharry Med Coll, Nashville, TN USA

[17] Icahn Sch Med Mt Sinai, New York, NY USA

[18] Univ Southern Calif, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA

[19] Univ Cambridge, Victor Phillip Dahdaleh Heart & Lung Res Inst, Dept Publ Hlth & Primary Care, Cambridge, England

[20] Univ Penn, Perelman Sch Med, Philadelphia, PA USA

[21] Morehouse Sch Med, Atlanta, GA USA

[22] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA USA

[23] Univ Alabama Birmingham, Birmingham Sch Med, Dept Neurol, Birmingham, AL USA

[24] Morehouse Sch Med, Dept Med, Atlanta, GA USA

[25] Natl Inst Minor Hlth & Hlth Dispar, Bethesda, MD USA

[26] Columbia Univ, Ctr Precis Med & Genom, New York, NY USA

[27] Columbia Univ, Dept Med Humanities & Eth, New York, NY USA

[28] Univ Chicago, Dept Publ Hlth Sci, Chicago, IL USA

[29] NIH, Common Fund, Bethesda, MD USA

[30] Univ Washington, Dept Pediat, Seattle, WA USA

[31] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

NATURE GENETICS | 2024年 / 56卷 / 05期

关键词：

SOCIAL DETERMINANTS; ANCESTRY; RACE;

D O I：

10.1038/s41588-024-01711-z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Health equity is the state in which everyone has fair and just opportunities to attain their highest level of health. The field of human genomics has fallen short in increasing health equity, largely because the diversity of the human population has been inadequately reflected among participants of genomics research. This lack of diversity leads to disparities that can have scientific and clinical consequences. Achieving health equity related to genomics will require greater effort in addressing inequities within the field. As part of the commitment of the National Human Genome Research Institute (NHGRI) to advancing health equity, it convened experts in genomics and health equity research to make recommendations and performed a review of current literature to identify the landscape of gaps and opportunities at the interface between human genomics and health equity research. This Perspective describes these findings and examines health equity within the context of human genomics and genomic medicine. This Perspective discusses how addressing disparities in genomics can drive improvements in health equity more broadly.

引用

页码：752 / 757

页数：6

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