Transmission of trained immunity and heterologous resistance to infections across generations

被引：0
|
作者：
Natalie Katzmarski
Jorge Domínguez-Andrés
Branko Cirovic
Georgios Renieris
Eleonora Ciarlo
Didier Le Roy
Konstantin Lepikhov
Kathrin Kattler
Gilles Gasparoni
Kristian Händler
Heidi Theis
Marc Beyer
Jos W. M. van der Meer
Leo A. B. Joosten
Jörn Walter
Joachim L. Schultze
Thierry Roger
Evangelos J. Giamarellos-Bourboulis
Andreas Schlitzer
Mihai G. Netea
机构：
[1] University of Bonn,Quantitative Systems Biology, Life and Medical Sciences Institute
[2] Radboud University Nijmegen Medical Centre,Department of Internal Medicine and Radboud Center for Infectious diseases
[3] Radboud University Medical Center,Radboud Institute for Molecular Life Sciences
[4] National and Kapodistrian University of Athens,Department 4th of Internal Medicine
[5] Medical School,Infectious Diseases Service, Department of Medicine
[6] Lausanne University Hospital and University of Lausanne,Department of Genetics/Epigenetics
[7] Saarland University,Molecular Immunology in Neurodegeneration
[8] Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn,Department for Genomics & Immunoregulation, Life and Medical Sciences Institute
[9] German Center for Neurodegenerative Diseases,Department for Immunology & Metabolism, Life and Medical Sciences Institute
[10] University of Bonn,undefined
[11] University of Bonn,undefined
来源：
Nature Immunology | 2021年 / 22卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous Escherichia coli and Listeria monocytogenes infections. Sperm DNA of parental male mice intravenously infected with the fungus C. albicans showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections.
引用
收藏
页码：1382 / 1390
页数：8
相关论文
共 50 条
  • [1] Transmission of trained immunity and heterologous resistance to infections across generations
    Israeli, Eitan
    [J]. ISRAEL MEDICAL ASSOCIATION JOURNAL, 2021, 23 (11): : 744 - 744
  • [2] Transmission of trained immunity and heterologous resistance to infections across generations
    Katzmarski, Natalie
    Dominguez-Andres, Jorge
    Cirovic, Branko
    Renieris, Georgios
    Ciarlo, Eleonora
    Le Roy, Didier
    Lepikhov, Konstantin
    Kattler, Kathrin
    Gasparoni, Gilles
    Handler, Kristian
    Theis, Heidi
    Beyer, Marc
    van der Meer, Jos W. M.
    Joosten, Leo A. B.
    Walter, Jorn
    Schultze, Joachim L.
    Roger, Thierry
    Giamarellos-Bourboulis, Evangelos J.
    Schlitzer, Andreas
    Netea, Mihai G.
    [J]. NATURE IMMUNOLOGY, 2021, 22 (11) : 1382 - +
  • [3] Transmission of trained immunity and heterologous resistance to infections across generations
    Katzmarski, N.
    Dominguez-Andres, J.
    Cirovic, B.
    Renieris, G.
    Ciarlo, E.
    Le Roy, D.
    Kattler, K.
    Gasparoni, G.
    Lepikhov, K.
    Haendler, K.
    Theis, H.
    Beyer, M.
    van der Meer, J. W. M.
    Joosten, L. A. B.
    Walter, J.
    Schultze, J. L.
    Giamarellos-Bourboulis, E. J.
    Schlitzer, A.
    Netea, M. G.
    Roger, T.
    [J]. SWISS MEDICAL WEEKLY, 2022, 152 : 24S - 24S
  • [4] Author Correction: Transmission of trained immunity and heterologous resistance to infections across generations
    Natalie Katzmarski
    Jorge Domínguez-Andrés
    Branko Cirovic
    Georgios Renieris
    Eleonora Ciarlo
    Didier Le Roy
    Konstantin Lepikhov
    Kathrin Kattler
    Gilles Gasparoni
    Kristian Händler
    Heidi Theis
    Marc Beyer
    Jos W. M. van der Meer
    Leo A. B. Joosten
    Jörn Walter
    Joachim L. Schultze
    Thierry Roger
    Evangelos J. Giamarellos-Bourboulis
    Andreas Schlitzer
    Mihai G. Netea
    [J]. Nature Immunology, 2023, 24 : 371 - 372
  • [5] Transmission of trained immunity and heterologous resistance to infections across generations ( 10.1038/s41590-021-01052-7, 2021)
    Katzmarski, Natalie
    Dominguez-Andres, Jorge
    Cirovic, Branko
    Renieris, Georgios
    Ciarlo, Eleonora
    Le Roy, Didier
    Lepikhov, Konstantin
    Kattler, Kathrin
    Gasparoni, Gilles
    Haendler, Kristian
    Theis, Heidi
    Beyer, Marc
    van der Meer, Jos W. M.
    Joosten, Leo A. B.
    Walter, Joern
    Schultze, Joachim L.
    Roger, Thierry
    Giamarellos-Bourboulis, Evangelos J.
    Schlitzer, Andreas
    Netea, Mihai G.
    [J]. NATURE IMMUNOLOGY, 2023, 24 (02) : 371 - 372
  • [6] Heterologous effects of vaccination and trained immunity
    Gyssens, I. C.
    Netea, M. G.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (12) : 1457 - 1458
  • [7] Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections
    Agrawal, Babita
    [J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [8] Trained immunity across organs
    Paula Jauregui
    [J]. Nature Immunology, 2024, 25 (9) : 1509 - 1509
  • [9] Trained immunity-related vaccines: innate immune memory and heterologous protection against infections
    Ziogas, Athanasios
    Netea, Mihai G.
    [J]. TRENDS IN MOLECULAR MEDICINE, 2022, 28 (06) : 497 - 512
  • [10] Trained immunity: consequences for the heterologous effects of BCG vaccination
    Kleinnijenhuis, Johanneke
    van Crevel, Reinout
    Netea, Mihai G.
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2015, 109 (01) : 29 - 35
12345