Optimized base editors enable efficient editing in cells, organoids and mice

被引:0
|
作者
Maria Paz Zafra
Emma M Schatoff
Alyna Katti
Miguel Foronda
Marco Breinig
Anabel Y Schweitzer
Amber Simon
Teng Han
Sukanya Goswami
Emma Montgomery
Jordana Thibado
Edward R Kastenhuber
Francisco J Sánchez-Rivera
Junwei Shi
Christopher R Vakoc
Scott W Lowe
Darjus F Tschaharganeh
Lukas E Dow
机构
[1] Sandra and Edward Meyer Cancer Center,Department of Medicine
[2] Weill Cornell Medicine,Department of Cancer Biology
[3] Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD–PhD program,Department of Biochemistry
[4] Weill Cornell Graduate School of Medical Sciences,undefined
[5] Weill Cornell Medicine,undefined
[6] Helmholtz-University Group 'Cell Plasticity and Epigenetic Remodeling',undefined
[7] German Cancer Research Center (DKFZ) and Institute of Pathology,undefined
[8] University Hospital,undefined
[9] Cancer Biology and Genetics,undefined
[10] Memorial Sloan Kettering Cancer Center,undefined
[11] Gerstner Sloan Kettering Graduate School of Biomedical Sciences,undefined
[12] Cold Spring Harbor Laboratory,undefined
[13] Perelman School of Medicine,undefined
[14] University of Pennsylvania,undefined
[15] Howard Hughes Medical Institute,undefined
[16] Memorial Sloan Kettering Cancer Center,undefined
[17] Weill Cornell Medicine,undefined
来源
Nature Biotechnology | 2018年 / 36卷
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中图分类号
学科分类号
摘要
The efficiency of base editing is substantially increased by optimizing expression and nuclear localization of the editing enzymes.
引用
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页码:888 / 893
页数:5
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