There is a long and interesting history in the study of the positive and negative effects of sacrifice, but few researchers have focused on how one’s marital partner being the recipient of sacrifice may lead to different outcomes. Based on conservation of resources theory, we suggested that a partner’s social support could be a potential moderator between sacrifice and well-being. To examine our hypothesis, we invited 141 Taiwanese couples to participate in our study. As expected, we found that only for those individuals whose partners provided less social support to them, the more they sacrificed, the lower marital satisfaction and the higher depressive symptoms they reported. In contrast, this effect was not found for the context in which a partner provided more social support. In addition, the negative correlation between a partner’s sacrifice and one’s depressive symptoms became stronger when an individual provided more support to their sacrificing partner. Our findings highlight that the relationship between sacrifice and well-being are contingent upon context, and are particularly dependent on whether the recipient of sacrifice can provide a supportive relationship.