Evidence of linkage between the serotonin transporter and autistic disorder

被引：0
|
作者：
Cook Jr. E.H. [1 ,5 ]
Courchesne R. [2 ]
Lord C. [2 ]
Cox N.J. [3 ]
Van S. [1 ]
Lincoln A. [2 ]
Haas R. [2 ]
Courchesne E. [2 ,4 ]
Leventhal B.L. [1 ]
机构：
[1] Lab. of Developmental Neuroscience, Department of Psychiatry, University of Chicago, Chicago, IL 60637
[2] Autism/Brain Devmt. Res. Laboratory, Children's Hospital, Research Center, San Diego, CA 92037
[3] Department of Medicine, University of Chicago, Chicago, IL 60637
[4] Neuroscience Department, School of Medicine, Univ. of California at San Diego, San Diego
[5] MC 3077, University of Chicago, Chicago, IL 60637
来源：
Molecular Psychiatry | 1997年 / 2卷 / 3期
关键词：
Autism; Infantile; Linkage; Linkage disequilibrium; Monoamines; Polymorphism; Promoter; Serotonin; Transporter;
D O I：
10.1038/sj.mp.4000266
中图分类号：
学科分类号：
摘要：
The serotonin transporter gene (HTT) is a primary candidate in autistic disorder based on efficacy of potent serotonin transporter inhibitors in reducing rituals and routines. We initiated a candidate gene study of HTT in trios consisting of probands with autistic disorder and both parents. Preliminary transmission/disequilibrium test (TDT) analysis with 86 families revealed no evidence for linkage or linkage disequilibrium between autistic disorder and a polymorphism in the second intron of HTT. However, preferential transmission of a short variant of the HTT promoter was found in the same 86 trios (TDT χ2 = 4.69, 1 d.f., P = 0.030). In further analyses, we considered haplotypes of the HTT promoter variant and second intron locus as alleles in a multiallelic TDT. Results confirmed the significance of the effect of this region (TDT χ2 = 11.85, 4 d.f., P = 0.018). This provides preliminary evidence of linkage and association between HTT and autistic disorder.
引用
下载
收藏
页码：247 / 250
页数：3
相关论文
共 50 条
  • [1] Evidence of linkage between the serotonin transporter and autistic disorder
    Cook, EH
    Courchesne, R
    Lord, C
    Cox, NJ
    Yan, S
    Lincoln, A
    Haas, R
    Courchesne, E
    Leventhal, BL
    MOLECULAR PSYCHIATRY, 1997, 2 (03) : 247 - 250
  • [2] Evidence for linkage disequilibrium between several markers in the serotonin transporter gene (SLC6A4) and autistic disorder
    Kim, SJ
    Cox, N
    Lord, C
    Courchesne, R
    Leventhal, BL
    Courchesne, E
    Cook, EH
    BIOLOGICAL PSYCHIATRY, 2001, 49 (08) : 84S - 84S
  • [3] Evidence for linkage disequilibrium between serotonin transporter protein and obsessive compulsive disorder.
    McDougle, CJ
    Epperson, CN
    Price, LH
    Gelernter, J
    AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (04) : A315 - A315
  • [4] Preliminary evidence of linkage and association between HTT and autistic disorder
    Cook, E
    Lord, C
    Courchesne, R
    Cox, N
    Yan, S
    Lincoln, A
    Haas, R
    Leventhal, B
    Corchesne, F
    BIOLOGICAL PSYCHIATRY, 1997, 41 : 132 - 132
  • [5] Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder
    Betancur C.
    Corbex M.
    Spielewoy C.
    Philippe A.
    Laplanche J.-L.
    Launay J.-M.
    Gillberg C.
    Mouren-Siméoni M.-C.
    Hamon M.
    Giros B.
    Nosten-Bertrand M.
    Leboyer M.
    Gillberg C.
    Rastam M.
    Gillberg C.
    Nydén A.
    Molecular Psychiatry, 2002, 7 (1) : 67 - 71
  • [6] Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder
    Betancur, C
    Corbex, M
    Spielewoy, C
    Philippe, A
    Laplanche, JL
    Launay, JM
    Gillberg, C
    Mouren-Siméoni, MC
    Hamon, M
    Giros, B
    Nosten-Bertrand, M
    Leboyer, M
    MOLECULAR PSYCHIATRY, 2002, 7 (01) : 67 - 71
  • [7] Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder
    Greenwood, TA
    Alexander, M
    Keck, PE
    McElroy, S
    Sadovnick, AD
    Remick, RA
    Kelsoe, JR
    AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (02): : 145 - 151
  • [8] Lack of linkage disequilibrium between serotonin transporter gene and bipolar disorder.
    Mundo, E
    Macciardi, F
    Walker, M
    Parikh, S
    Tims, H
    Kennedy, JL
    MOLECULAR PSYCHIATRY, 1999, 4 : S92 - S93
  • [9] Genetic linkage study of bipolar disorder and the serotonin transporter
    Kelsoe, JR
    Remick, RA
    Sadovnick, AD
    Kristbjarnarson, H
    Flodman, P
    Spence, MA
    Morison, M
    MroczkowskiParker, Z
    Bergesch, P
    Rapaport, MH
    Mirow, AL
    Blakely, RD
    Helgason, T
    Egeland, JA
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1996, 67 (02): : 215 - 217
  • [10] Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder
    McDougle, CJ
    Epperson, CN
    Price, LH
    Gelernter, J
    MOLECULAR PSYCHIATRY, 1998, 3 (03) : 270 - 273
12345