Phosphorylation of NLRC4 is critical for inflammasome activation

被引：0
|
作者：
Yan Qu
Shahram Misaghi
Anita Izrael-Tomasevic
Kim Newton
Laurie L. Gilmour
Mohamed Lamkanfi
Salina Louie
Nobuhiko Kayagaki
Jinfeng Liu
László Kömüves
James E. Cupp
David Arnott
Denise Monack
Vishva M. Dixit
机构：
[1] Genentech Inc.,Department of Physiological Chemistry
[2] 1 DNA Way,Department of Early Stage Cell Culture
[3] South San Francisco,Department of Protein Chemistry
[4] California 94080,Department of Immunology
[5] USA,Department of Medical Protein Research
[6] Genentech Inc.,Department of Biochemistry
[7] 1 DNA Way,Department of Bioinformatics and Computational BiologyGenentech Inc.
[8] South San Francisco,Department of Pathology
[9] California 94080,Department of Microbiology and Immunology
[10] USA,undefined
[11] Genentech Inc.,undefined
[12] 1 DNA Way,undefined
[13] South San Francisco,undefined
[14] California 94080,undefined
[15] USA,undefined
[16] Genentech Inc.,undefined
[17] 1 DNA Way,undefined
[18] South San Francisco,undefined
[19] California 94080,undefined
[20] USA,undefined
[21] VIB,undefined
[22] B-9000 Ghent,undefined
[23] Belgium,undefined
[24] Ghent University,undefined
[25] B-9000 Ghent,undefined
[26] Belgium,undefined
[27] 1 DNA Way,undefined
[28] Genentech Inc.,undefined
[29] 1 DNA Way,undefined
[30] South San Francisco,undefined
[31] California 94080,undefined
[32] USA,undefined
[33] Stanford School of Medicine,undefined
来源：
Nature | 2012年 / 490卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Phosphorylation of the NOD-like receptor NLRC4 is essential for activation of the NLRC4 inflammasome complex in response to bacterial stimuli.
引用
收藏
页码：539 / 542
页数：3
相关论文
共 50 条
  • [1] Phosphorylation of NLRC4 is critical for inflammasome activation
    Qu, Yan
    Misaghi, Shahram
    Izrael-Tomasevic, Anita
    Newton, Kim
    Gilmour, Laurie L.
    Lamkanfi, Mohamed
    Louie, Salina
    Kayagaki, Nobuhiko
    Liu, Jinfeng
    Koemueves, Laszlo
    Cupp, James E.
    Arnott, David
    Monack, Denise
    Dixit, Vishva M.
    [J]. NATURE, 2012, 490 (7421) : 539 - +
  • [2] Vimentin Regulates Activation of the NLRC4 Inflammasome
    Cheng, Yuan
    Davis, Jennifer
    Lu, Ziyan
    Gates, Khalilah
    Coates, Bria
    Ridge, Karen
    [J]. FASEB JOURNAL, 2017, 31
  • [3] The NLRC4 Inflammasome
    Duncan, Joseph A.
    Canna, Scott W.
    [J]. IMMUNOLOGICAL REVIEWS, 2018, 281 (01) : 115 - 123
  • [4] Advances in Understanding Activation and Function of the NLRC4 Inflammasome
    Sundaram, Balamurugan
    Kanneganti, Thirumala-Devi
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (03) : 1 - 12
  • [5] Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
    Matusiak, Magdalena
    Van Opdenbosch, Nina
    Vande Walle, Lieselotte
    Sirard, Jean-Claude
    Kanneganti, Thirumala-Devi
    Lamkanfi, Mohamed
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (05) : 1541 - 1546
  • [6] CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT
    Mohamed, Mohamed F.
    Gupta, Kajal
    Goldufsky, Josef W.
    Roy, Ruchi
    Callaghan, Lauren T.
    Wetzel, Dawn M.
    Kuzel, Timothy M.
    Reiser, Jochen
    Shafikhani, Sasha H.
    [J]. NATURE COMMUNICATIONS, 2022, 13 (01)
  • [7] CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT
    Mohamed F. Mohamed
    Kajal Gupta
    Josef W. Goldufsky
    Ruchi Roy
    Lauren T. Callaghan
    Dawn M. Wetzel
    Timothy M. Kuzel
    Jochen Reiser
    Sasha H. Shafikhani
    [J]. Nature Communications, 13
  • [8] Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation
    Gong, Yi-Nan
    Shao, Feng
    [J]. PROTEIN & CELL, 2012, 3 (02) : 98 - 105
  • [9] The induction of NLRC4 Inflammasome Activation in Photoreceptor mitochondrial oxidative stress
    Saraswathy, Sindhu
    Rao, Narsing
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)
  • [10] NLRC4 suppresses melanoma tumor progression independently of inflammasome activation
    Janowski, Ann M.
    Colegio, Oscar R.
    Hornick, Emma E.
    McNiff, Jennifer M.
    Martin, Matthew D.
    Badovinac, Vladimir P.
    Norian, Lyse A.
    Zhang, Weizhou
    Cassel, Suzanne L.
    Sutterwala, Fayyaz S.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (10): : 3917 - 3928
12345