Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

被引：0

作者：

Chiara Gorrini

Massimo Squatrito

Chiara Luise

Nelofer Syed

Daniele Perna

Landon Wark

Francesca Martinato

Domenico Sardella

Alessandro Verrecchia

Samantha Bennett

Stefano Confalonieri

Matteo Cesaroni

Francesco Marchesi

Milena Gasco

Eugenio Scanziani

Maria Capra

Sabine Mai

Paolo Nuciforo

Tim Crook

John Lough

Bruno Amati

机构：

[1] European Institute of Oncology (IEO),Department of Experimental Oncology

[2] FIRC Institute of Molecular Oncology (IFOM),Department of Veterinary Pathology

[3] IFOM-IEO Campus,Department of Medical Oncology

[4] Milan 20139,undefined

[5] Italy,undefined

[6] Breakthrough Breast Cancer Research Centre,undefined

[7] The Institute of Cancer Research,undefined

[8] Chester Beatty Laboratories,undefined

[9] London,undefined

[10] SW3 6JB,undefined

[11] UK,undefined

[12] Manitoba Institute of Cell Biology and The Genomic Center for Cancer,undefined

[13] Research and Diagnosis,undefined

[14] CancerCare Manitoba,undefined

[15] University of Manitoba,undefined

[16] Winnipeg,undefined

[17] Manitoba R3E 0V9,undefined

[18] Canada,undefined

[19] Hygiene and Public Health,undefined

[20] Section of Veterinary and Avian Pathology,undefined

[21] University of Milan,undefined

[22] San Croce e Carle Hospital,undefined

[23] Medical College of Wisconsin,undefined

[24] Milwaukee,undefined

[25] Wisconsin 53226,undefined

[26] USA,undefined

[27] Present address: Department of Cancer Biology and Genetics,undefined

[28] Memorial Sloan-Kettering Cancer Center,undefined

[29] New York,undefined

[30] New York 10021,undefined

[31] USA.,undefined

来源：

Nature | 2007年 / 448卷

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摘要：

The acetyl-transferase Tip60 regulates transcription and is involved in the DNA damage response. Now it has been found to have tumour suppressor activity in vivo both in a mouse model and in human tumours. The human Tip60 locus (HTATIP) is frequently mutated in head and neck squamous cell carcinoma, breast carcinoma and lymphomas. Nuclear Tip60 staining on tissue microarrays is lost in a variety of tumours, and most significantly in breast carcinomas. This work suggests that critical levels of Tip60 are required for mounting an oncogene-induced DNA damage response in incipient tumour cells: the failure of this defence mechanism may synergize with p53 mutation towards tumour progression.

引用

页码：1063 / 1067

页数：4

共 42 条

[1] Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Gorrini, Chiara
Squatrito, Massimo
Luise, Chiara
Syed, Nelofer
Perna, Daniele
Wark, Landon
Martinato, Francesca
Sardella, Domenico
Verrecchia, Alessandro
Bennett, Samantha
Confalonieri, Stefano
Cesaroni, Matteo
Marchesi, Francesco
Gasco, Milena
Scanziani, Eugenio
Capra, Maria
Mai, Sabine
Nuciforo, Paolo
Crook, Tim
Lough, John
Amati, Bruno
NATURE, 2007, 448 (7157) : 1063 - U12
[2] Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
Sun, Yingli
Jiang, Xiaofeng
Xu, Ye
Ayrapetov, Marina K.
Moreau, Lisa A.
Whetstine, Johnathan R.
Price, Brendan D.
NATURE CELL BIOLOGY, 2009, 11 (11) : 1376 - U273
[3] Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
Yingli Sun
Xiaofeng Jiang
Ye Xu
Marina K. Ayrapetov
Lisa A. Moreau
Johnathan R. Whetstine
Brendan D. Price
Nature Cell Biology, 2009, 11 : 1376 - 1382
[4] Herpesviruses control the DNA damage response through TIP60
Renfeng Li
Jian Zhu
Zhi Xie
Gangling Liao
Shaohui Hu
Crystal Woodard
Jimmy Lin
Gary S Hayward
Jiang Qian
Heng Zhu
S Diane Hayward
Infectious Agents and Cancer, 7 (Suppl 1)
[5] A Posttranslational Modification Cascade Involving p38, Tip60, and PRAK Mediates Oncogene-Induced Senescence
Zheng, Hui
Seit-Nebi, Alim
Han, Xuemei
Aslanian, Aaron
Tat, John
Liao, Rong
Yates, John R., III
Sun, Peiqing
MOLECULAR CELL, 2013, 50 (05) : 699 - 710
[6] TIP60 contributes to porcine embryonic development by regulating DNA damage response
Guo, Jing
Zhou, Wenjun
Niu, Ying-Jie
Shin, Kyung-Tae
Heo, Young Tae
Kim, Nam-Hyung
Cui, Xiang-Shun
THERIOGENOLOGY, 2018, 108 : 146 - 152
[7] Defining the role of Tip60 in the DNA damage response of glioma cell lines
Bannik, K.
Sak, A.
Groneberg, M.
Stuschke, M.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2024,
[8] Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
Di Micco, Raffaella
Fumagalli, Marzia
Cicalese, Angelo
Piccinin, Sara
Gasparini, Patrizia
Luise, Chiara
Schurra, Catherine
Garre, Massimiliano
Nuciforo, Paolo Giovanni
Bensimon, Aaron
Maestro, Roberta
Pelicci, Pier Giuseppe
di Fagagna, Fabrizio d'Adda
NATURE, 2006, 444 (7119) : 638 - 642
[9] Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
Raffaella Di Micco
Marzia Fumagalli
Angelo Cicalese
Sara Piccinin
Patrizia Gasparini
Chiara Luise
Catherine Schurra
Massimiliano Garre’
Paolo Giovanni Nuciforo
Aaron Bensimon
Roberta Maestro
Pier Giuseppe Pelicci
Fabrizio d’Adda di Fagagna
Nature, 2006, 444 : 638 - 642
[10] Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
Raffaella Di Micco
Gabriele Sulli
Miryana Dobreva
Michalis Liontos
Oronza A. Botrugno
Gaetano Gargiulo
Roberto dal Zuffo
Valentina Matti
Giovanni d'Ario
Erica Montani
Ciro Mercurio
William C. Hahn
Vassilis Gorgoulis
Saverio Minucci
Fabrizio d'Adda di Fagagna
Nature Cell Biology, 2011, 13 : 292 - 302

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