Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus

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作者
Kyoko Tossell
Xiao Yu
Panagiotis Giannos
Berta Anuncibay Soto
Mathieu Nollet
Raquel Yustos
Giulia Miracca
Mikal Vicente
Andawei Miao
Bryan Hsieh
Ying Ma
Alexei L. Vyssotski
Tim Constandinou
Nicholas P. Franks
William Wisden
机构
[1] Imperial College London,Department of Life Sciences
[2] Chinese Academy of Sciences,Center for Excellence in Brain Science and Intelligence Technology
[3] Imperial College London,UK Dementia Research Institute
[4] Imperial College London,Department of Electrical and Electronic Engineering
[5] Imperial College London,Center for Neurotechnology
[6] University of Zürich–ETH Zürich,Institute of Neuroinformatics
[7] UK Dementia Research Institute,Care Research and Technology Centre
来源
Nature Neuroscience | 2023年 / 26卷
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摘要
The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state could be ‘tiredness’. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFCSst-GABA) cells that responded to sleep deprivation. These cells projected to the lateral preoptic (LPO) hypothalamus and the lateral hypothalamus (LH). Stimulating PFCSst-GABA terminals in the LPO hypothalamus caused sleep-preparatory behavior (nesting, elevated theta power and elevated temperature), and stimulating PFCSst-GABA terminals in the LH mimicked recovery sleep (non-rapid eye-movement sleep with higher delta power and lower body temperature). PFCSst-GABA terminals had enhanced activity during nesting and sleep, inducing inhibitory postsynaptic currents on diverse cells in the LPO hypothalamus and the LH. The PFC also might feature in deciding sleep location in the absence of excessive fatigue. These findings suggest that the PFC instructs the hypothalamus to ensure that optimal sleep takes place in a suitable place.
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页码:1805 / 1819
页数:14
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