Absence of p16 gene (CDKN2) deletions in microdissected primary breast carcinoma specimens

被引：0
|
作者：
Jacqueline E. Calvano
Elisa B. Rush
Lee K. Tan
Paul Peter Rosen
Patrick I. Borgen
Kimberly J. Van Zee
机构：
[1] Memorial Sloan-Kettering Cancer Center,Department of Pathology
[2] Memorial Sloan-Kettering Cancer Center,Breast Service, Department of Surgery
来源：
Annals of Surgical Oncology | 1997年 / 4卷
关键词：
p16; (; ); MTS1; Breast carcinoma; Microdissection; Genetic alterations;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: The p16 gene (CDKN2), a tumor suppressor gene located on chromosome 9p21, has been demonstrated to be mutated or deleted with high frequency in a variety of tumor cell lines, including breast. While previous studies have not demonstratedCDKN2 mutations in primary breast carcinomas, it is possible that gene deletion in neoplastic DNA was masked by the presence of contaminating normal stromal DNA in breast carcinoma specimens.
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页码：416 / 420
页数：4
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