Protective Effect of Carnosine on Cu,Zn-Superoxide Dismutase during Impaired Oxidative Metabolism in the Brain in Vivo

被引：0

作者：

S. L. Stvolinskii

T. N. Fedorova

M. O. Yuneva

A. A. Boldyrev

机构：

[1] Institute of Neurology,Russian Academy of Medical Sciences

来源：

Bulletin of Experimental Biology and Medicine | 2003年 / 135卷

关键词：

hypoxia; senescence accelerated mice (SAMP); Cu,Zn-SOD; brain; carnosine; antioxidants;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Natural hydrophilic antioxidant carnosine protects cerebral cytosolic Cu,Zn-superoxide dismutase (SOD) under conditions of oxidative stress in various in vivo models: short-term hypobaric hypoxia in rats and accumulation of age-related changes in senescence-accelerated mice (SAMP). Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice.

引用

页码：130 / 132

页数：2

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