YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilisI. Fermentation, Isolation and Biological Activities

被引：0

作者：

Kin-ya Sohda

Koji Nagai

Takao Yamori

Ken-ichi Suzuki

Akihiro Tanaka

机构：

[1] Institute for Drug Discovery Research,Division of Molecular Pharmacology

[2] Yamanouchi Pharmaceutical Co.,Corporate Communications Department

[3] Ltd.,undefined

[4] Cancer Chemotherapy Center,undefined

[5] Japanese Foundation for Cancer Research,undefined

[6] Institute for Drug Discovery Research,undefined

[7] Yamanouchi Pharmaceutical Co.,undefined

[8] Ltd.,undefined

[9] Yamanouchi Pharmaceutical Co.,undefined

[10] Ltd.,undefined

来源：

The Journal of Antibiotics | 2005年 / 58卷

关键词：

YM-216391; cyclic peptide; trisoxazole; cytotoxic;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

YM-216391, a novel cyclic peptide, was isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. It was purified by solvent extraction, silica gel and ODS flash column chromatographies, followed by preparative HPLC. YM-216391 dose-dependently inhibited the growth of human cervical cancer HeLa S3 cells with an IC50 value of 14 nM. YM-216391 also showed potent cytotoxic activity against a human cancer cell line panel.

引用

页码：27 / 31

页数：4

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