CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer

被引：0

作者：

Olafur A Stefansson

Manel Esteller

机构：

[1] Bellvitge Biomedical Research Institute (IDIBELL),Cancer Epigenetics and Biology Program (PEBC)

[2] Av. Gran Via de L’Hospitalet 199-203,Cancer Research Laboratory

[3] L’Hospitalet del Llobregat,Department of Physiological Sciences II

[4] Faculty of Medicine,undefined

[5] University of Iceland,undefined

[6] School of Medicine,undefined

[7] University of Barcelona,undefined

[8] Institució Catalana de Recerca i Estudis Avançats (ICREA),undefined

来源：

Breast Cancer Research | / 16卷

关键词：

Chromatin Remodel; Arginine Residue; MCF7 Breast Cancer Cell; Recurrent Mutation; Methyltransferase Activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues. This modification leads to the relocalization of BAF155-containing SWI/SNF complexes to regions containing genes involved in the Myc oncogenic pathway. The results presented are evidence that these interactions constitute a mechanism by which the BAF155 chromatin remodeling factor contributes to cancer.

引用

共 9 条

[1] CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer
Stefansson, Olafur A.
Esteller, Manel
BREAST CANCER RESEARCH, 2014, 16 (03):
[2] CARM1 methylates BAF155 and perturbs chromatin remodeling machinery to enhance tumor progression
Wang, Lu
MOLECULAR CANCER RESEARCH, 2013, 11
[3] CARM1 methylates BAF155 and perturbs chromatin remodeling machinery to enhance tumor progression
Wang, Lu
Zhao, Zibo
Meyer, Mark
Pike, Wesley J.
Xu, Wei
CANCER RESEARCH, 2013, 73
[4] CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis
Wang, Lu
Zhao, Zibo
Meyer, Mark B.
Saha, Sandeep
Yu, Menggang
Guo, Ailan
Wisinski, Kari B.
Huang, Wei
Cai, Weibo
Pike, J. Wesley
Yuan, Ming
Ahlquist, Paul
Xu, Wei
CANCER CELL, 2014, 25 (01) : 21 - 36
[5] CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis (vol 25, pg 21, 2014)
Wang, Lu
Zhao, Zibo
Meyer, Mark B.
Saha, Sandeep
Yu, Menggang
Guo, Ailan
Wisinski, Kari B.
Huang, Wei
Cai, Weibo
Pike, J. Wesley
Yuan, Ming
Ahlquist, Paul
Xu, Wei
CANCER CELL, 2016, 30 (01) : 179 - 180
[6] Characterization of the loss of BAF155 of the SWI/SNF chromatin remodeling complex in human cancer cell lines
Delbove, Jessica N.
Stroebeck, Matthew W.
Knudsen, Erik S.
Wang, Weidong
Archer, Trevor K.
Chen, Jianguang
Weissman, Bernard E.
CANCER RESEARCH, 2006, 66 (08)
[7] CARM1-mediated BAF155 methylation promotes metastasis and is targetable to reduce disparate mortality in triple negative breast cancer
Kim, Eui-Jun
Liu, Peng
Wang, Yidan
Ong, Irene M.
Xu, Wei
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2023, 32 (01) : 260 - 261
[8] CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development
Chen, Xue
Huang, Ming-feng
Fan, Da-meng
He, Yao-hui
Zhang, Wen-juan
Ding, Jian-cheng
Peng, Bing-ling
Pan, Xu
Liu, Ya
Du, Jun
Li, Ying
Liu, Zhi-ying
Xie, Bing-lan
Kuang, Zhi-jian
Yi, Jia
Liu, Wen
NUCLEIC ACIDS RESEARCH, 2024, 52 (12) : 6811 - 6829
[9] 1H, 15N, and 13C resonance assignments and secondary structure of the SWIRM domain of human BAF155, a chromatin remodeling complex component
Moon, Sunjin
Shin, Joon
Lee, Dongju
Seong, Rho H.
Lee, Weontae
MOLECULES AND CELLS, 2013, 36 (04) : 333 - 339

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