The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase

被引：0
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作者：
Matthew W Vetting
Subray S Hegde
John S Blanchard
机构：
[1] Albert Einstein College of Medicine,Department of Biochemistry
来源：
Nature Chemical Biology | 2010年 / 6卷
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摘要：
Some cyclodipeptides are unusual in that their cyclic scaffold is created from activated, amino-acid–loaded tRNA substrates. Structural and biochemical evidence now demonstrates that the enzymes that perform this reaction are homologous to tRNA synthetases and use a covalently bound intermediate.[graphic not available: see fulltext]
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页码：797 / 799
页数：2
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