Patient-centric trials for therapeutic development in precision oncology

被引：0

作者：

Andrew V. Biankin

Steven Piantadosi

Simon J. Hollingsworth

机构：

[1] Wolfson Wohl Cancer Research Centre,Cancer Division

[2] Institute of Cancer Sciences,Department of Surgery

[3] University of Glasgow,undefined

[4] The Kinghorn Cancer Centre,undefined

[5] Garvan Institute of Medical Research,undefined

[6] Bankstown Hospital,undefined

[7] South Western Sydney Clinical School,undefined

[8] Faculty of Medicine,undefined

[9] University of New South Wales,undefined

[10] Samuel Oschin Comprehensive Cancer Institute,undefined

[11] Cedars-Sinai Medical Center,undefined

[12] Innovative Medicines & Early Development Oncology,undefined

[13] AstraZeneca,undefined

[14] Cambridge Science Park,undefined

来源：

Nature | 2015年 / 526卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine.

引用

页码：361 / 370

页数：9

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