Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome

被引：0

作者：

M. L. Kukushkin

S. I. Igon’kina

M. V. Churyukanov

V. V. Churyukanov

M. Yu. Bobrov

V. V. Bezuglov

N. V. Gretskaya

机构：

[1] Russian Academy of Medical Sciences,Laboratory of Pathophysiology, Institute of Pathology and Pathophysiology

[2] Russian Academy of Sciences,M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry

[3] Ministry of Health of Russia,I. M. Setchenov Moscow Medical Academy

来源：

Bulletin of Experimental Biology and Medicine | 2006年 / 142卷

关键词：

central pain syndrome; analgesia; cannabinoidergic system; anandamide; WIN 55,212-2;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We studied the effect of cannabinoid receptor agonists anandamide and WIN 55,212-2 on the central pain syndrome induced by intraspinal injection of penicillin sodium salt in rats. Cannabinoids suppressed allodynia and spontaneous attacks in rats with the central pain syndrome. The analgesic effect was most pronounced after intrathecal injection of cannabinoid receptor agonist in a dose of 100 µg in 10 µl. After systemic treatment the analgesic effect was produced by only WIN 55,212-2 in a dose of 1 mg/kg. WIN 55,212-2 was superior to anandamide by the duration and intensity of the effect on allodynia and spontaneous attacks.

引用

页码：39 / 42

页数：3

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