679 Cerebrospinal Fluid Oligoclonal Bands and Igg in Children

Introduction: Cerebrospinal fluid examination may be an essential aid in the diagnostic process of many neurological diseases in children as well as in adult patients The detection of oligoclonal bands and the assessment of IgG index contribute to information about the intrathecal production of oligoclonal IgG that may possibly occur in many neurological diseases This includes mainly demyelinating and inflammatory diseases, but elevated IgG index and/or positive oligoclonal bands can be detected also in other conditions, such as neoplastic disorders or neurometabolic diseases/ progressive encephalopaties (PE) Intrathecal immunoglobulin synthesis can be measured either quantitatively, using the IgG index, or /and qualitatively by oligoclonal bands detection.