The effects of NMDA receptor antagonists on acute morphine antinociception in mice

被引：0
|
作者：
E. Kozela
P. Popik
机构：
[1] Institute of Pharmacology,
[2] Polish Academy of Sciences,undefined
[3] Kraków,undefined
[4] Poland,undefined
来源：
Amino Acids | 2002年 / 23卷
关键词：
Keywords: Opiates; Morphine; Antinociception; Pain; NMDA receptor antagonists; Glutamate;
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摘要：
 Antagonists of the N-methyl-d-aspartate (NMDA) receptor complex inhibit the development of tolerance to antinociceptive effects of morphine and upon acute administration, influence morphine antinociceptive activity. The analysis of numerous studies investigating acute interaction between NMDA receptor antagonists and morphine in mice indicate a variety of procedural differences and reveal that these compounds may potentiate, attenuate and produce no effect on morphine antinociception. The conditions responsible for such conflicting experimental outcome of acute interaction remain unclear. It appears that the effects of NMDA receptor antagonists on morphine tolerance are not causally related to their acute effects on morphine antinociception.
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页码：163 / 168
页数：5
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