Age-related changes in lymphocyte development and function

被引：0
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作者：
Phyllis Jean Linton
Kenneth Dorshkind
机构：
[1] Phyllis Jean Linton is at the Sidney Kimmel Cancer Center,Department of Pathology and Laboratory Medicine and the Hematopoietic Malignancies Program
[2] Jonsson Comprehensive Cancer Center,undefined
[3] David Geffen School of Medicine at UCLA,undefined
来源：
Nature Immunology | 2004年 / 5卷
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摘要：
The effects of aging on the immune system are widespread and extend from hematopoietic stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes in secondary lymphoid organs. These changes combine to result in a diminution of immune responsiveness in the elderly. This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research.
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页码：133 / 139
页数：6
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