Successful immunotherapy in early relapse of acute myeloid leukemia after nonmyeloablative allogeneic stem cell transplantation

被引：0
|
作者：
E. Prinz
F. Keil
P. Kalhs
M. Mitterbauer
W. Rabitsch
A. Rosenmayr
K. Moser
A. Schulenburg
K. Lechner
H. T. Greinix
机构：
[1] University Hospital of Vienna,Department of Medicine I, Bone Marrow Transplantation
[2] University Hospital of Vienna,Department of Blood Group Serology and Austrian Stem Cell Donor Registry
来源：
Annals of Hematology | 2003年 / 82卷
关键词：
AML; Nonmyeloablative allogeneic stem cell transplantation; Immunotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We report on a 35-year-old woman who underwent allogeneic stem cell transplantation (SCT) in second complete remission (CR) of acute myeloid leukemia (AML) after reduced-intensity conditioning with fludarabine and 2 Gy of total body irradiation. For graft-versus-host disease (GVHD) prophylaxis, cyclosporin A (CsA) and mycophenolate mofetil (MMF) were given. On day 27 after SCT complete hematological remission and donor chimerism was documented. However, in CD34+ bone marrow cells 28% of recipient hematopoiesis persisted. On day +59 leukemic relapse occurred. After discontinuation of CsA and onset of GVHD, complete donor chimerism and hematological CR were achieved which has been maintained for 14 months.
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页码：295 / 298
页数：3
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