Class III β-tubulin immunoreactive intranuclear inclusions in human ependymomas and gangliogliomas

被引：0
|
作者：
J. Woulfe
机构：
[1] Department of Pathology and Molecular Medicine,
[2] McMaster University,undefined
[3] and Department of Laboratory Medicine,undefined
[4] Hamilton Health Sciences Corporation,undefined
[5] General Division,undefined
[6] 237 Barton St. East,undefined
[7] Hamilton,undefined
[8] Ontario,undefined
[9] Canada L8L 2X2,undefined
来源：
Acta Neuropathologica | 2000年 / 100卷
关键词：
Key words Ependymoma; Ganglioglioma; Immunohistochemistry; Intranuclear inclusions; Tubulin;
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摘要：
We have observed intranuclear inclusion bodies immunoreactive for the cytoskeletal protein class III β tubulin (C3βT) in neurons and ependymal cells of post-mortem human brain. The relationship of these inclusions, detected by light microscopy, to the intranuclear rodlets described by the classical microscopists is unknown. The present study was conducted to determine whether these proteinaceous inclusions (C3βT-NIIs) exist in the neoplastic counterparts of these cell types. Immunohistochemical staining for C3βT revealed intensely stained, predominantly rod-shaped intranuclear inclusions in a variable proportion of tumor cells in five of ten ependymomas. In addition, C3βT-NIIs were encountered in less than 1% of neuronal cells in two of five gangliogliomas. This study represents the first report of tubulin-containing intranuclear inclusions in brain tumors. The functional significance of these inclusions in normal human brain and in cerebral neuroepithelial neoplasms remains to be determined.
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页码：427 / 434
页数：7
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