Cosmetic changes following surgery and accelerated partial breast irradiation using HDR interstitial brachytherapy: Evaluation by a multidisciplinary/multigender committee; [Kosmetische Veränderungen nach Operation und akzellerierter Teilbrustbestrahlung mittels HDR-interstitieller Brachytherapie: Auswertung durch einen multidisziplinären Multigender-Ausschuss]

被引：0

作者：

Soror T. ^{[1
,2
]}

Kovács G. ^{[1
]}

Seibold N. ^{[1
]}

Melchert C. ^{[1
]}

Baumann K. ^{[3
]}

Wenzel E. ^{[4
]}

Stojanovic-Rundic S. ^{[5
]}

机构：

[1] Interdisciplinary Brachytherapy Unit, University of Luebeck/UKSH-CL, Ratzeburger Allee 160, Luebeck

[2] National Cancer Institute (NCI), Radiation Oncology Department, Cairo University, Cairo

[3] Clinic for Gynecology and Obstetrics, University of Luebeck/UKSH-CL, Luebeck

[4] Clinic for Plastic Surgery, University of Luebeck/UKSH-CL, Luebeck

[5] Institute for Oncology and Radiology (IORS), Medical School University of Belgrade, Belgrade

来源：

Strahlentherapie und Onkologie | 2017年 / 193卷 / 5期

关键词：

Breast cancer; Breast-conserving surgery; Photographs; Survival; Toxicity;

D O I：

10.1007/s00066-016-1093-6

中图分类号：

学科分类号：

摘要：

Background: Patients with early-stage breast cancer can benefit from adjuvant accelerated partial breast irradiation (APBI) following breast-conserving surgery (BCS). This work reports on cosmetic results following APBI using multicatheter high-dose-rate interstitial brachytherapy (HDR-IBT). Patients and methods: Between 2006 and 2014, 114 patients received adjuvant APBI using multicatheter HDR-IBT. For each patient, two photographs were analyzed: the first was taken after surgery (baseline image) and the second at the last follow-up visit. Cosmesis was assessed by a multigender multidisciplinary team using the Harvard Breast Cosmesis Scale. Dose–volume histogram (DVH) parameters and the observed cosmetic results were investigated for potential correlations. Results: The median follow-up period was 3.5 years (range 0.6–8.5 years). The final cosmetic scores were 30% excellent, 52% good, 14.5% fair, and 3.5% poor. Comparing the baseline and follow-up photographs, 59.6% of patients had the same score, 36% had a better final score, and 4.4% had a worse final score. Only lower target dose nonuniformity ratio (DNR) values (0.3 vs. 0.26; p = 0.009) were significantly associated with improved cosmetic outcome vs. same/worse cosmesis. Conclusion: APBI using multicatheter HDR-IBT adjuvant to BCS results in favorable final cosmesis. Deterioration in breast cosmesis occurs in less than 5% of patients. The final breast cosmetic outcome in patients treated with BCS and APBI using multicatheter HDR-IBT is influenced primarily by the cosmetic result of the surgery. A lower DNR value is significantly associated with a better cosmetic outcome. © 2017, Springer-Verlag Berlin Heidelberg.

引用

页码：367 / 374

页数：7