General Framework for the Prediction of Oral Drug Interactions Caused by CYP3A4 Induction from In Vivo Information

被引：0
|
作者：
Yoshiyuki Ohno
Akihiro Hisaka
Masaki Ueno
Hiroshi Suzuki
机构：
[1] University of Tokyo Hospital,Department of Pharmacy
[2] Faculty of Medicine,Pharmacology and Pharmacokinetics
[3] University of Tokyo,Center for Advanced Medical Engineering and Informatics
[4] University of Tokyo Hospital,undefined
[5] Faculty of Medicine,undefined
[6] University of Tokyo,undefined
[7] Osaka University,undefined
来源：
Clinical Pharmacokinetics | 2008年 / 47卷
关键词：
Simvastatin; Rifampicin; Pioglitazone; Efavirenz; Substrate Drug;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Induction of cytochrome P450 (CYP) 3A4 potentially reduces the blood concentrations of substrate drugs to less than one-tenth, which results in ineffective pharmacotherapy. Although the prediction of drug-drug interactions (DDIs) that are mediated by induction of CYP3A4 has been performed mainly on the basis of in vitro information, such methods have met with limited success in terms of their accuracy and applicability. Therefore, a realistic method for the prediction of CYP3A4-mediated inductive DDIs is of major clinical importance.
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页码：669 / 680
页数：11
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