Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal

被引:0
|
作者
Gaber El-Saber Batiha
Hayder M. Al-kuraishy
Ali I. Al-Gareeb
Mubarak Alruwaili
Raed AlRuwaili
Sarah M. Albogami
Mohammed Alorabi
Hebatallah M. Saad
Jesus Simal-Gandara
机构
[1] Damanhour University,Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine
[2] Mustansiriyah University,Professor in department of clinical pharmacology and medicine, College of Medicine
[3] Jouf University,Department of Internal Medicine, College of Medicine
[4] Taif University,Department of Biotechnology, College of Science
[5] Matrouh University,Department of Pathology, Faculty of Veterinary Medicine
[6] Universidade de Vigo,Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science
来源
Inflammopharmacology | 2023年 / 31卷
关键词
Covid-19; Neuroinflammation; Glibenclamide;
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学科分类号
摘要
In coronavirus disease 2019 (Covid-19) era, neuroinflammation may develop due to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and/or associated immune activation, cytokine storm, and psychological stress. SARS-CoV-2 infection and linked cytokine storm may cause blood–brain barrier (BBB) injury through which activated immune cells and SARS-CoV-2 can pass into the brain causing activation of glial cells with subsequent neuroinflammation. Different therapeutic regimens were suggested to alleviate Covid-19-induced neuroinflammation. Since glibenclamide has anti-inflammatory and neuroprotective effects, it could be effective in mitigation of SARS-CoV-2 infection-induced neuroinflammation. Glibenclamide is a second-generation drug from the sulfonylurea family, which acts by inhibiting the adenosine triphosphate (ATP)-sensitive K channel in the regulatory subunit of type 1 sulfonylurea receptor (SUR-1) in pancreatic β cells. Glibenclamide reduces neuroinflammation and associated BBB injury by inhibiting the nod-like receptor pyrin 3 (NLRP3) inflammasome, oxidative stress, and microglial activation. Therefore, glibenclamide through inhibition of NLRP3 inflammasome, microglial activation, and oxidative stress may attenuate SARS-CoV-2-mediated neuroinflammation.
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页码:1 / 7
页数:6
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