Erratum: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

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作者
L. Pastorino
A. Sun
P.-J. Lu
X. Z. Zhou
M. Balastik
G. Finn
G. Wulf
J. Lim
S.-H. Li
X. Li
W. Xia
L. K. Nicholson
K. P. Lu
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Nature | 2007年 / 446卷
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Nature 440, 528–534 (2006) During editing to meet Nature’s limits on length, we removed a reference to an earlier paper1 reporting that the prolyl isomerase Pin1 promotes production of Alzheimer’s amyloid-β (Aβ) from β-cleaved amyloid precursor protein (APP). That paper reported that Pin1 did not bind to full-length APP, but rather to the phosphorylated Thr 668–Pro motif of the carboxy-terminal C99 fragment of APP; Aβ production in Pin1-knockout mice was reduced only from this fragment.
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页码:342 / 342
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