Novel approach for the synthesis of N-unsubstituted 2,3,5,6-tetrahydro-4H-2,6-methano-1,3-benzoxazocine-4-thiones

被引：0

作者：

Alexander V. Borisov

Svitlana S. Kovalenko

Sergiy M. Kovalenko

机构：

[1] Latvian Institute of Organic Synthesis,

[2] Enamine Ltd.,undefined

[3] National University of Pharmacy,undefined

[4] V. N. Karazin Kharkiv National University,undefined

来源：

Chemistry of Heterocyclic Compounds | 2015年 / 51卷

关键词：

lortalamine; 2,6-methano-1,3-benzoxazocine-4-thiones; 6-methano-1,3-benzoxazocin-4-one; pyridoxal; tandem reaction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An efficient one-pot method for the synthesis of 2,3,5,6-tetrahydro-4H-2,6-methano-1,3-benzoxazocine-4-thiones in high yields has been developed via regioselective tandem reaction of coumarin-3-thioamides and ketones containing different methylene groups. Further oxidation with hydrogen peroxide under basic conditions leads to the formation of N-unsubstituted derivatives of 2,3,5,6-tetrahydro-4H-2,6-methano-1,3-benzoxazocin-4-one.

引用

页码：678 / 681

页数：3

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