Cortical miscommunication after prenatal exposure to alcohol

被引:0
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作者
Scott M. Lewis
Rosa R. Vydrová
Arthur C. Leuthold
Apostolos P. Georgopoulos
机构
[1] Minneapolis VA Health Care System,Brain Sciences Center (11B)
[2] University of Minnesota,Department of Neurology
[3] University Hospital Motol,Department of Pediatric Neurology, Charles University, 2nd Faculty of Medicine
[4] University of Minnesota,Department of Neuroscience
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Magnetoencephalography; Fetal alcohol syndrome; Synchronous neural interactions; Resting state;
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摘要
We report on the effects of prenatal alcohol exposure on resting-state brain activity as measured by magnetoencephalography (MEG). We studied 37 subjects diagnosed with fetal alcohol spectrum disorder in one of three categories: fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder. For each subject, the MEG signal was recorded for 60 s during rest while subjects lay supine. Using time series analysis, we calculated the synchronous neural interactions for all pair-wise combinations of 248 MEG sensors resulting in 30,628 partial correlations for each subject. We found significant differences from control subjects in 6.19 % of the partial zero-lag crosscorrelations (synchronous neural interactions; Georgopoulos et al. in J Neural Eng 4:349–355, 2007), with these differences localized in the right posterior frontal, right parietal, and left parietal/posterior frontal regions. These results show that MEG can detect functional brain differences in the individuals affected by prenatal exposure to alcohol. Furthermore, these differences may serve as a biomarker for future studies linking symptoms and signs to specific brain areas. This may lead to new insights into the neuropathology of fetal alcohol spectrum disorders.
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页码:3347 / 3353
页数:6
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