Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomes

被引:0
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作者
Muhui Zeng
Xiaoshuai Wang
Tianyu Chen
Guangfeng Ruan
Jia Li
Song Xue
Yang Zhao
Zhiyang Hu
Ye Xie
Tianxiang Fan
Shibo Chen
Yang Li
Qianyi Wang
Yue Zhang
Rongkai Zhang
Lijun Lin
Changhai Ding
Zhaohua Zhu
机构
[1] Zhujiang Hospital,Clinical Research Centre
[2] Southern Medical University,Department of Orthopedics
[3] General Hospital of Southern Theater Command of PLA,Department of Orthopedics
[4] Zhujiang Hospital,Department of Orthopedics
[5] Southern Medical University,Clinical Research Centre
[6] The Third Affiliated Hospital of Southern Medical University,Department of Rheumatology and Immunology
[7] Guangzhou First People’s Hospital,Sun Yat
[8] School of Medicine,sen University School of Medicine
[9] South China University of Technology,Zhongshan School of Medicine
[10] Arthritis Research Institute,State Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences
[11] The First Affiliated Hospital of Anhui Medical University,undefined
[12] Sun Yat-sen University,undefined
[13] Sun Yat-sen University,undefined
[14] Southern Medical University,undefined
[15] Menzies Institute for Medical Research,undefined
[16] University of Tasmania,undefined
关键词
Osteoarthritis; Subchondral bone; Bone marrow lesions; Deconvolution algorithm; Single-cell RNA sequencing;
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学科分类号
摘要
1. IL11 and VCAN were identified as the core hub genes of BMLs in OA.
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