A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study

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作者
Matthew C. Kostek
Joseph M. Devaney
Heather Gordish-Dressman
Tamara B. Harris
Paul D. Thompson
Priscilla M. Clarkson
Theodore J. Angelopoulos
Paul M. Gordon
Niall M. Moyna
Linda S. Pescatello
Paul S. Visich
Robert F. Zoeller
Richard L. Seip
Melissa Garcia
Rongling Li
Joseph M. Zmuda
Matthew J. Delmonico
Alka Kanaya
Eric P. Hoffman
机构
[1] University of South Carolina,Department of Exercise Science
[2] Children’s National Medical Center,Research Center for Genetic Medicine
[3] National Institutes of Health,National Institute of Aging
[4] Henry Low Heart Center,Division of Cardiology
[5] Hartford Hospital,Department of Kinesiology, Totman Building
[6] University of Massachusetts,Center for Lifestyle Medicine
[7] University of Central Florida,Department of Physical Medicine and Rehabilitation
[8] University of Michigan,Department of Sport Science and Health
[9] Dublin City University,Department of Kinesiology, School of Education
[10] University of Connecticut,Human Performance Laboratory
[11] Central Michigan University,Department of Exercise Science and Health Promotion
[12] Florida Atlantic University,Department of Preventive Medicine
[13] University of Tennessee,Department of Human Genetics
[14] University of Pittsburgh,Department of Kinesiology
[15] University of Rhode Island,Division of General Internal Medicine
[16] University of California-San Francisco,undefined
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关键词
IGF1; Muscle; Body composition; Bone mineral density; Elderly; SNP;
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摘要
Previous studies have reported associations of polymorphisms in the IGF1 gene with phenotypes of body composition (BC). The purpose of this study was to identify phenotypes of BC and physical function that were associated with the IGF1 promoter polymorphism (rs35767, −C1245T). Subjects from the Health, Aging, and Body Composition Study, white males and females (n = 925/836) and black males and females (533/705) aged 70–79 years were genotyped for the polymorphism. Phenotypes of muscle size and function, bone mineral density, and BC were analyzed for associations with this polymorphism. To validate and compare these findings, a cohort of young (mean age = 24.6, SD = 5.9) white men and women (n = 173/296) with similar phenotypic measurements were genotyped. An association with BC was identified in elderly females when significant covariates (physical activity, age, smoking status, body mass index) were included. White women with C/C genotype had 3% more trunk fat and 2% more total fat than those with C/T (P < 0.05). Black women with C/C genotype had 3% less total lean mass and 3% less muscle mass than their T/T counterparts (P < 0.05). Associations were identified with muscle strength in white women (P < 0.01) that were in agreement with the C/C genotype having lower muscle function. Thus, in an elderly population but not a young population, a polymorphism in the IGF1 gene may be predictive of differences in body composition, primarily in black females.
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页码:315 / 324
页数:9
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