What’s New in HIV/AIDS? Chemokine Receptor Antagonists: A New Era of HIV Therapy?

被引：0
|
作者：
B. Jülg
F. D. Goebel
机构：
[1] Ludwig Maximilian University Munich,Dept. of Infectious Diseases, Medical Policlinic
来源：
Infection | 2005年 / 33卷
关键词：
Public Health; Internal Medicine; Human Immunodeficiency Virus; Infectious Disease; Receptor Antagonist;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chemokine receptors are essential for human immunodeficiency virus (HIV) cell entry. CXCR4 and CCR5 are the two most relevant receptors and by inhibition of each of them a delayed onset of disease could be achieved. As both receptors are used at different stages of disease due to the domination of different HIV strains, a dual blockage of CXCR4 and CCR5 could be highly valuable for inhibiting viral transmission and replication.
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页码：408 / 410
页数：2
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