Development and Characterization of Zein-Based Micro Carrier System for Sustained Delivery of Aceclofenac Sodium

被引：0
|
作者：
K. Karthikeyan
Rachita Lakra
Rama Rajaram
Purna Sai Korrapati
机构：
[1] Central Leather Research Institute,Biomaterials Division
来源：
AAPS PharmSciTech | 2012年 / 13卷
关键词：
biopolymers; drug delivery; gastric injury; NSAIDs; zein microspheres;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability of zein microspheres at gastric pH retarded the release of the entrapped drug and hence reduces the possibility of gastric injury. However, the in vitro release of aceclofenac was sustained up to 72 h at intestinal pH. Thus, zein microspheres pave the way for the development of safe and sustained delivery system for NSAIDs thereby achieving the desired therapeutic potential with reduced side effects for chronic inflammatory disorders.
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页码：143 / 149
页数：6
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