Structural basis of lentiviral subversion of a cellular protein degradation pathway

被引：0
|
作者：
David Schwefel
Harriet C. T. Groom
Virginie C. Boucherit
Evangelos Christodoulou
Philip A. Walker
Jonathan P. Stoye
Kate N. Bishop
Ian A. Taylor
机构：
[1] MRC National Institute for Medical Research,Division of Molecular Structure
[2] The Ridgeway,Division of Virology
[3] Mill Hill,undefined
[4] London NW7 1AA,undefined
[5] UK,undefined
[6] MRC National Institute for Medical Research,undefined
[7] The Ridgeway,undefined
[8] Mill Hill,undefined
[9] London NW7 1AA,undefined
[10] UK,undefined
来源：
Nature | 2014年 / 505卷
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摘要：
The crystal structure of a ternary complex of the lentiviral accessory protein Vpx with the E3 ligase substrate adaptor DCAF1 and the HIV-1 restriction factor SAMHD1 shows how Vpx recruits SAMHD1 to the cell’s ubiquitination machinery.
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页码：234 / 238
页数：4
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