Paradoxical sleep deprivation increases mortality in myocardial infarcted rats

被引：0
|
作者：
Rafael S. Carvalho
Juliana C. Perry
Ruy R. Campos
Monica L. Andersen
Sergio Tufik
Cássia T. Bergamaschi
机构：
[1] Universidade Federal de São Paulo,Cardiovascular Division, Department of Physiology
[2] Federal University of São Paulo,Departments of Psychobiology
来源：
Sleep and Biological Rhythms | 2014年 / 12卷
关键词：
cardiovascular system; isoproterenol; myocardial infarction; sleep; sleep deprivation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We hypothesized that sleep deprivation affects hemodynamic parameters and, therefore, correlates with mortality after acute myocardial infarction (AMI) induced by isoproterenol. Rats were randomly assigned to one of four experimental groups: control, paradoxical sleep deprivation (PSD), AMI, and PSD + AMI. Blood pressure, heart rate and renal sympathetic nerve activity were higher in the PSD group. Mortality after isoproterenol administration was significantly higher in the PSD + AMI group compared to the AMI group. These data suggest that sleep loss is able to increase cardiovascular risk, per se, and worsens the prognosis in cases of cardiac insult.
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页码：216 / 219
页数：3
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