Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

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机构：

[1] School of Public Health,Department of Biostatistics

[2] University of Michigan,Division of Gastroenterology

[3] Massachusetts General Hospital,Division of Cancer Epidemiology and Genetics, Department of Health and Human Services

[4] Metabolism Initiative and Program in Medical and Population Genetics,Department of Molecular Biology

[5] Broad Institute of Harvard and Massachusetts Institute of Technology,Program in Genomics and Divisions of Endocrinology and Genetics

[6] Medical Research Council Epidemiology Unit,Division of Community Health Sciences

[7] Addenbrooke's Hospital,Department of Nutrition

[8] Institute of Metabolic Science,Department of Medicine

[9] Addenbrooke's Hospital,Department of Biostatistics

[10] Wellcome Trust Centre for Human Genetics,Department of Internal Medicine

[11] University of Oxford,Department of Twin Research and Genetic Epidemiology

[12] Institute of Epidemiology,Department of Social Medicine

[13] Helmholtz Zentrum München,Department of Clinical Sciences

[14] Ingolstaedter Landstr. 1,Department of Epidemiology and Public Health

[15] National Cancer Institute,Department of Child and Adolescent Psychiatry

[16] National Institutes of Health,Department of Epidemiology

[17] Program in Medical and Population Genetics,Department of Medical Genetics

[18] Broad Institute of MIT and Harvard,Department of Public Health and Primary Care

[19] Massachusetts General Hospital,Department of Molecular Medicine

[20] Children's Hospital,Department of Medicine

[21] Medical Genetics/Clinical Pharmacology and Discovery Medicine,Department of Cardiovascular Sciences

[22] King of Prussia,Department of Social Medicine

[23] St. George's,Department of Oral & Dental Science

[24] University of London,Department of Clinical Sciences

[25] Harvard School of Public Health,Department of Clinical Chemistry

[26] Channing Laboratory,Department of Haematology

[27] Brigham and Women's Hospital,Department of Epidemiology and Health Promotion

[28] Wellcome Trust Sanger Institute,Department of Internal Medicine

[29] Hinxton,Department of Preventive Medicine, Division of Biostatistics

[30] Istituto di Neurogenetica e Neurofarmacologia,Department of Medicine

[31] Consiglio Nazionale delle Ricerche,Department of Medicine

[32] Center for Statistical Genetics,Department of Genetics

[33] University of Michigan,Department of Genetics

[34] Genetics of Complex Traits,undefined

[35] Peninsula Medical School,undefined

[36] Erasmus MC,undefined

[37] PO Box 2400,undefined

[38] Oxford Centre for Diabetes,undefined

[39] Endocrinology and Metabolism,undefined

[40] University of Oxford,undefined

[41] Churchill Hospital,undefined

[42] Oxford OX3 7LJ,undefined

[43] UK.,undefined

[44] King's College London,undefined

[45] National Institute of Aging,undefined

[46] Clinical Research Branch - Longitudinal Studies Section,undefined

[47] MRC Centre for Causal Analyses in Translational Epidemiology,undefined

[48] University of Bristol,undefined

[49] Lund University Diabetes Centre,undefined

[50] Lund University,undefined

来源：

Nature Genetics | 2009年 / 41卷

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摘要：

Joel Hirschhorn and colleagues report results of a large-scale genome-wide association and replication study for obesity-related traits. The newly discovered loci are enriched for genes expressed in the central nervous system, and may thus contribute to weight gain by modulating food intake. Similar results are reported in a related study by Gudmar Thorleifsson and colleagues.

引用

页码：25 / 34

页数：9

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