The Effect of Brucella abortus on Hydrogen Peroxide and Nitric Oxide Production by Bovine Polymorphonuclear Cells

被引：0
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作者：
L. Iyankan
D.K. Singh
机构：
[1] Indian Veterinary Research Institute,FAO/WHO Collaborating Centre for Research and Training in Veterinary Public Health, Division of Veterinary Public Health
来源：
Veterinary Research Communications | 2002年 / 26卷
关键词：
cattle; hydrogen peroxide; lipopolysaccharide; nitric oxide; outer membrane protein; reactive oxygen; vaccination;
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摘要：
The effect of Brucella on the generation of microbicidal reactive oxygen and nitrogen metabolites by bovine peripheral polymorphonuclear cells (PMNs) was investigated. The PMNs were recovered from the peripheral blood of control calves and experimental calves previously vaccinated against brucellosis. Significantly larger quantities of NO and H2O2 were generated by PMNs from control and experimental calves following activation by heat-killed whole cells or outer membrane protein of Brucella abortus than by non-activated cells (p<0.05–0.01). In contrast, generation of H2O2 and NO decreased when PMNs were exposed to the lipopolysaccharide of Brucella. However, the generation of H2O2 and NO by activated PMNs from the control and experimental calves did not differ significantly.
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页码：93 / 102
页数：9
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