3D-Printed Poly Lactic Acid Scaffolds with Tetrapod-Interlocked Structure Containing Dipyridamole

Poly lactic acid (PLA) filament containing dipyridamole (DIP) was prepared and DIP/PLA tetrapod-interlocked scaffold was printed by fused deposition modeling method. Tetrapod-interlocked structure was designed with CAD and translated into G-code with slic3r program. The mechanical property was investigated using universal testing machine. Compressive stress resistance of the tetrapod-interlocked structure was significantly increased. Meanwhile, release profile and osteoblast proliferation ability of tetrapod-interlocked scaffold with DIP was examined. Osteoblast proliferation was increased with the increasing amount of DIP. [graphic not available: see fulltext]