Chemical informatics and target identification in a zebrafish phenotypic screen

被引：0
|
作者：
Christian Laggner
David Kokel
Vincent Setola
Alexandra Tolia
Henry Lin
John J Irwin
Michael J Keiser
Chung Yan J Cheung
Daniel L Minor
Bryan L Roth
Randall T Peterson
Brian K Shoichet
机构：
[1] University of California,Department of Pharmaceutical Chemistry
[2] Massachusetts General Hospital,Cardiovascular Research Center and Division of Cardiology, Department of Medicine
[3] Harvard Medical School,Department of Pharmacology
[4] Broad Institute,Department of Biochemistry and Biophysics
[5] University of North Carolina Chapel Hill School of Medicine,undefined
[6] National Institute of Mental Health Psychoactive Drug Screening Program,undefined
[7] University of North Carolina Chapel Hill School of Medicine,undefined
[8] Cardiovascular Research Institute,undefined
[9] University of California,undefined
[10] University of California,undefined
来源：
Nature Chemical Biology | 2012年 / 8卷
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摘要：
A cheminformatics approach helps identify proteins such as GPCRs, ion channels and kinases that are targeted by small molecules that give phenotypes in a zebrafish behavioral assay.[graphic not available: see fulltext]
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页码：144 / 146
页数：2
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