A precision medicine–based, ‘fast-fail’ approach for psychiatry

被引:0
|
作者
Leanne M. Williams
Laura M. Hack
机构
[1] Psychiatry and Behavioral Sciences,
[2] Stanford University,undefined
[3] Mental Illness Research,undefined
[4] Education and Clinical Center,undefined
[5] VA Palo Alto Health Care System,undefined
来源
Nature Medicine | 2020年 / 26卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
A ‘fast-fail’ clinical-trial approach for depression indicates that engaging κ-opioid-receptor antagonism improves reward-circuit dysfunction and anhedonia.
引用
收藏
页码:653 / 654
页数:1
相关论文
共 50 条
  • [1] A precision medicine-based, 'fast-fail' approach for psychiatry
    Williams, Leanne M.
    Hack, Laura M.
    NATURE MEDICINE, 2020, 26 (05) : 653 - 654
  • [2] Fast-fail approach identifies promising anhedonia therapy
    Sarah Crunkhorn
    Nature Reviews Drug Discovery, 2020, 19 (5) : 310 - 310
  • [3] The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development
    Krystal, Andrew D.
    Pizzagalli, Diego A.
    Mathew, Sanjay J.
    Sanacora, Gerard
    Keefe, Richard
    Song, Allen
    Calabrese, Joseph
    Goddard, Andrew
    Goodman, Wayne
    Lisanby, Sarah H.
    Smoski, Moria
    Weiner, Richard
    Iosifescu, Dan
    Nurnberger, John
    Szabo, Steven
    Murrough, James
    Shekhar, Anantha
    Potter, William
    NATURE REVIEWS DRUG DISCOVERY, 2019, 18 (01) : 82 - 84
  • [4] The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development
    Andrew D. Krystal
    Diego A. Pizzagalli
    Sanjay J. Mathew
    Gerard Sanacora
    Richard Keefe
    Allen Song
    Joseph Calabrese
    Andrew Goddard
    Wayne Goodman
    Sarah H. Lisanby
    Moria Smoski
    Richard Weiner
    Dan Iosifescu
    John Nurnberger
    Steven Szabo
    James Murrough
    Anantha Shekhar
    William Potter
    Nature Reviews Drug Discovery, 2019, 18 : 82 - 84
  • [5] The NIMH 'Fast-Fail Trials' (FAST) Initiative: Rationale, Promise, and Progress
    Grabb, Margaret C.
    Hillefors, Mi
    Potter, William Z.
    PHARMACEUTICAL MEDICINE, 2020, 34 (04) : 233 - 245
  • [6] The NIMH ‘Fast-Fail Trials’ (FAST) Initiative: Rationale, Promise, and Progress
    Margaret C. Grabb
    Mi Hillefors
    William Z. Potter
    Pharmaceutical Medicine, 2020, 34 : 233 - 245
  • [7] Torching the Haystack: modelling fast-fail strategies in drug development
    Lendrem, Dennis W.
    Lendrem, B. Clare
    DRUG DISCOVERY TODAY, 2013, 18 (7-8) : 331 - 336
  • [8] A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia
    Krystal, Andrew D.
    Pizzagalli, Diego A.
    Smoski, Moria
    Mathew, Sanjay J.
    Nurnberger, John, Jr.
    Lisanby, Sarah H.
    Iosifescu, Dan
    Murrough, James W.
    Yang, Hongqiu
    Weiner, Richard D.
    Calabrese, Joseph R.
    Sanacora, Gerard
    Hermes, Gretchen
    Keefe, Richard S. E.
    Song, Allen
    Goodman, Wayne
    Szabo, Steven T.
    Whitton, Alexis E.
    Gao, Keming
    Potter, William Z.
    NATURE MEDICINE, 2020, 26 (05) : 760 - +
  • [9] A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia
    Andrew D. Krystal
    Diego A. Pizzagalli
    Moria Smoski
    Sanjay J. Mathew
    John Nurnberger
    Sarah H. Lisanby
    Dan Iosifescu
    James W. Murrough
    Hongqiu Yang
    Richard D. Weiner
    Joseph R. Calabrese
    Gerard Sanacora
    Gretchen Hermes
    Richard S. E. Keefe
    Allen Song
    Wayne Goodman
    Steven T. Szabo
    Alexis E. Whitton
    Keming Gao
    William Z. Potter
    Nature Medicine, 2020, 26 : 760 - 768
  • [10] Precision Medicine in Psychiatry
    Williams, Leanne M.
    PSYCHIATRIC ANNALS, 2024, 54 (04) : e101 - e102