Genetic linkage and association analyses for trait mapping in Plasmodium falciparum

被引：0
|
作者：
Xinzhuan Su
Karen Hayton
Thomas E. Wellems
机构：
[1] Laboratory of Malaria and Vector Research,
[2] National Institute of Allergy and Infectious Diseases,undefined
[3] National Institutes of Health,undefined
来源：
Nature Reviews Genetics | 2007年 / 8卷
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摘要：
This article discuss the foundations for genetic linkage mapping and population association analysis of the human malaria parasite Plasmodium falciparum.We review strategies of P. falciparum genetic crosses and of candidate-gene association, selection-based association and genome-wide association studies.We present an example of a trait (P. falciparum chloroquine resistance) that has been mapped to a single gene.We discuss the feasibility of dissecting complex traits that are determined by multiple genes.We survey methods for systematic and large-scale analysis of gene expression, polymorphism and selection.
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页码：497 / 506
页数：9
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