Prediction of In Vivo Interaction Between Triazolam and Erythromycin Based on In Vitro Studies Using Human Liver Microsomes and Recombinant Human CYP3A4

被引：0
|
作者：
Shin-ichi Kanamitsu
Kiyomi Ito
Carol E. Green
Charles A. Tyson
Noriaki Shimada
Yuichi Sugiyama
机构：
[1] University of Tokyo,Graduate School of Pharmaceutical Sciences
[2] Kitasato University,School of Pharmaceutical Sciences
[3] SRI International,Toxicology Laboratory
[4] Daiichi Pure Chemicals Co.,Research and Development Division
[5] LTD.,Graduate School of Pharmaceutical Sciences
[6] University of Tokyo,undefined
来源：
Pharmaceutical Research | 2000年 / 17卷
关键词：
drug interaction; mechanism-based inhibition; triazolam; erythromycin; physiologically-based pharmacokinetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To quantitatively predict the in vivo interaction betweentriazolam and erythromycin, which involves mechanism-basedinhibition of CYP3A4, from in vitro studies using human liver microsomes(HLM) and recombinant human CYP3A4 (REC).
引用
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页码：419 / 426
页数：7
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