Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum

被引：0

作者：

Rafael Franco

Verònica Casadó-Anguera

Ana Muñoz

Milos Petrovic

Gemma Navarro

Estefanía Moreno

José Luis Lanciego

José Luis Labandeira-García

Antoni Cortés

Vicent Casadó

机构：

[1] Instituto de Salud Carlos III,Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)

[2] University of Barcelona,Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology

[3] University of Santiago de Compostela,Laboratory of Neuroanatomy and Experimental Neurology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS)

[4] University of Central Lancashire,School of Pharmacy and Biomedical Sciences

[5] PR1 2HE,Laboratory of Neuroanatomy of Basal Ganglia, Neurosciences Division, Center for Applied Medical Research (CIMA)

[6] Institute of Physiology,undefined

[7] Academy of Sciences,undefined

[8] University of Navarra,undefined

来源：

Molecular Neurobiology | 2016年 / 53卷

关键词：

Lateralization; Basal ganglia; G-protein-coupled receptor dimer; Dyskinesia; 6-hydroxydopamine; Cooperativity index;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson’s disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from naïve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.

引用

页码：5436 / 5445

页数：9

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Casado-Anguera, Veronica
Munoz, Ana
Petrovic, Milos
Navarro, Gemma
Moreno, Estefania
Luis Lanciego, Jose
Luis Labandeira-Garcia, Jose
Cortes, Antoni
Casado, Vicent
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