Anhydride Prodrugs for Nonsteroidal Anti-Inflammatory Drugs

被引：0
|
作者：
Osnat Shaaya
Amir Magora
Tzviel Sheskin
Neeraj Kumar
Abraham J. Domb
机构：
[1] The Hebrew University of Jerusalem,Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine
[2] Israel Police National Headquarters,Division of Identification and Forensic Science
[3] Taro Research Institute Ltd.,undefined
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
mixed-anhydride; prodrugs; ibuprofen; NSAID; prolong-action;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The objective of this study was to synthesize anhydride prodrugs for prolong action to shield the carboxylic acid group from irritative effects and to temporary hydrophobize the drug so that it becomes accessible to aqueous media when the anhydride residue is hydrolyzed.
引用
收藏
页码：205 / 211
页数：6
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