MicroRNAs and atrial fibrillation: mechanisms and translational potential

被引：0
|
作者：
Xiaobin Luo
Baofeng Yang
Stanley Nattel
机构：
[1] Montreal Heart Institute and Université de Montréal,Department of Medicine and Research Centre
[2] Harbin Medical University,Department of Pharmacology
来源：
Nature Reviews Cardiology | 2015年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNAs are gene regulators with important pathophysiological roles in various cardiac conditions, including in atrial fibrillation (AF)Patients with AF have altered microRNA expression profiles in atrial tissue and in bloodCorrection of specific microRNA dysregulation can suppress AF in animal studiesSeveral in vivo microRNA interference approaches are under development that might be used for microRNA-targeted therapies in patients with AF in the futureAlthough microRNAs show promise as biomarkers and therapeutic targets in AF, considerable research is needed before their full potential can be realized
引用
收藏
页码：80 / 90
页数：10
相关论文
共 50 条
  • [1] MicroRNAs and atrial fibrillation: mechanisms and translational potential
    Luo, Xiaobin
    Yang, Baofeng
    Nattel, Stanley
    NATURE REVIEWS CARDIOLOGY, 2015, 12 (02) : 80 - 90
  • [2] MicroRNAs in Atrial Fibrillation: Mechanisms, Vascular Implications, and Therapeutic Potential
    Vardas, Emmanouil P.
    Theofilis, Panagiotis
    Oikonomou, Evangelos
    Vardas, Panos E.
    Tousoulis, Dimitris
    BIOMEDICINES, 2024, 12 (04)
  • [3] The Therapeutic Potential of MicroRNAs in Atrial Fibrillation
    Xu, Xiaona
    Zhao, Zhiqiang
    Li, Guangping
    MEDIATORS OF INFLAMMATION, 2020, 2020
  • [4] Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal
    Schotten, Ulrich
    Verheule, Sander
    Kirchhof, Paulus
    Goette, Andreas
    PHYSIOLOGICAL REVIEWS, 2011, 91 (01) : 265 - 325
  • [5] Circulating MicroRNAs as Potential Biomarkers of Atrial Fibrillation
    Gomes da Silva, Ananilia Medeiros
    Goes de Araujo, Jessica Nayara
    Costa de Freitas, Renata Caroline
    Silbiger, Vivian Nogueira
    BIOMED RESEARCH INTERNATIONAL, 2017, 2017
  • [6] Molecular mechanisms of atrial fibrillation. Potential role of microRNAs as new therapeutic targets and potential biomarkers
    Wakili, R.
    Clauss, S.
    Kaeaeb, S.
    HERZ, 2012, 37 (02) : 166 - 171
  • [7] MicroRNAs in Atrial Fibrillation: Pathophysiological Aspects and Potential Biomarkers
    Chaulin, Aleksey M.
    Duplyakov, Dmitriy, V
    INTERNATIONAL JOURNAL OF BIOMEDICINE, 2020, 10 (03) : 198 - 205
  • [8] Mapping atrial fibrillation An overview of potential mechanisms underlying atrial fibrillation
    Kowalewski, Christopher
    HERZ, 2021, 46 (04) : 305 - 311
  • [9] MicroRNAs in Atrial Fibrillation
    Briasoulis, Alexandros
    Sharma, Shikha
    Telila, Tesfaniye
    Mallikethi-Reddy, Sagar
    Papageorgiou, Nikolaos
    Oikonomou, Evangelos
    Tousoulis, Dimitris
    CURRENT MEDICINAL CHEMISTRY, 2019, 26 (05) : 855 - 863
  • [10] Atrial fibrillation and microRNAs
    Santulli, Gaetano
    Iaccarino, Guido
    De Luca, Nicola
    Trimarco, Bruno
    Condorelli, Gianluigi
    FRONTIERS IN PHYSIOLOGY, 2014, 5
12345