Complement receptor type two (CR2,CR21)A target for influencing the humoral immune response and antigen-trapping

被引：0
|
作者：
Wolfgang M. Prodinger
机构：
[1] University of Innsbruck,Institut für Hygiene
来源：
Immunologic Research | 1999年 / 20卷
关键词：
Complement; C3; Receptor; CD21; Structure; Immunity; EBV; Therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cellular receptors for complement C3 fragments deposited on antigens are important bricks in the wall defending against microbial pathogens. The part of complement receptor type 2 (CR2; CD21) deals with enhancing humoral immune responses and with long-term trapping of C3d-coated antigen by follicular dendritic cells. CR2 is also pivotal for Epstein-Barr virus (EBV) infection. Here, the current understanding, how CR2 interacts with its ligands C3d, EBV, and CD23 is summarized. The potential to target CR2 for clinical therapy or immunization purposes are discussed.
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页码：187 / 194
页数：7
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